, to explore how the connection between adhesin and its target fibrinogen peptide can withstand huge forces greater than 2 nano-Newtons , researchers used a combination of atomic force microscopy and GPU-accelerated molecular dynamics simulations using Central to biofilm formation is an unusually tight interaction between microbial surface proteins called adhesins and the extracellular components of the host cells. Particularly vulnerable areas are medical devices such as artificial joints or cardiac pacemakers, where the bacteria strongly stick to through formation of biofilms. Not surprisingly, staph infections are the leading cause of healthcare-related, so called nosocomial infections.
However, when staph bacteria enter a person's bloodstream, they can travel to locations deep within the body causing infections that are often hard to treat. Staph infections are caused by bacteria commonly found on the skin of healthy individuals, where they can only cause relatively minor skin problems. The structure of one such supercomplex (termed Alternative complex III) was determined at an atomic resolution through a combination of cryoEM and advanced molecular modeling and simulation tools performed with In a recent paper reporting a three-way collaboration between biochemists, However, sometimes these enzymes can form a supercomplex that positions the enzymes very close to each other and with the right pose for faster electron transfer and therefore more efficient energy conversion. Typically, one enzyme passes an electron to its downstream enzyme via random collisions. Thus generating a transmembrane voltage (much like a battery) that can be used for ATP synthesis. Many bacteria pass electrons to oxygen or other acceptors with the help of membrane-bound enzymes, Bacteria are remarkable at tailoring their bioenergetic machineries to adapt to and thrive in diverse and ever-changing environments.Ī critical metabolic task is the efficient extraction of energy from food.
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